Investigator, Biocatalysis Chemistry

Job description

Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Aug 24 2020

An exciting opportunity in the GlaxoSmithKline Synthetic Biochemistry group has just opened up.  The primary focus of this role is to support the discovery and implementation of novel enzyme-based applications at GSK, by participating in the development, screening and optimization of biocatalytic reactions, as well as the exploration of novel applications of directed evolution within GSK’s portfolio of research and discovery.  The successful candidate would participate on an interdisciplinary team tasked with providing fit for purpose enzymes to chemistry and biology project teams and broader.

This role will provide YOU the opportunity to lead key activities to progress YOUR career.  These responsibilities include some of the following:

  • Interact with process chemists and engineers to determine process parameters under which an enzyme must perform.
  • Develop appropriate surrogates for process conditions in order to authentically replicate target process conditions in high throughput
  • When appropriate, develop immobilized process conditions for enzyme candidates generated from protein engineering efforts.
  • Express, test and rank enzyme variants in both HTP and shake flask scales.
  • Work with molecular biologists, bioinformaticians, and process chemists to identify and resolve barriers to enzyme evolution.
  • Manipulate large-scale datasets using MS Excel and equipment interfacing programs.
  • Liaise with scientists & external collaborators at all levels
  • Generate conclusion reports, present data in team meetings & participate in writing of abstracts & publications
  • Conduct scientific work programs and make contributions both independently and as a member of a team with other R&D staff
  • Work through problems logically and apply innovative solutions (appropriate to grade)
  • Adopt new technologies and apply them to project work
  • Maintain customer focus, motivate self, and demonstrate a high degree of urgency
  • Use scientific literature and database resources in the execution of project related work
  • Exhibit flexibility, being open to new ways of working


Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

  • Ph.D. in Chemistry, Biotechnology, Chemical Biology, or related field with 1-2 years relevant experience
  • Significant hands-on experience in the discovery, development and scale-up of organic reactions
  • Experience in enzyme characterization including a background in mechanistic and kinetic studies of enzymatic reactions (Vmax, Km, product inhibition, substrate inhibition, cofactors, redox chemistry)

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

  • Demonstrated ability to work in multi-disciplinary teams, displaying excellent interpersonal, organizational, and communication skills

  • Experience in the discovery, development and scale-up of enzyme catalyzed organic reactions

  • Experience with parallel experimentation, high throughput assay development, Design of Experiments, etc.

  • Experience in the development of miniaturized biochemical assays to drive enzyme evolution toward conditions relevant to industrial manufacturing

  • Understanding of protein engineering/expression tools and techniques

  • Broad knowledge of organic chemistry, with particular emphasis on biocatalysis and chirality

  • Familiarity with or interest in learning automation equipment

Why GSK?

Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities:

  • Operating at pace and agile decision-making – using evidence and applying judgement to balance pace, rigour and risk.
  • Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution.
  • Continuously looking for opportunities to learn, build skills and share learning.
  • Sustaining energy and well-being
  • Building strong relationships and collaboration, honest and open conversations.
  • Budgeting and cost-consciousness

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